Step 1: Preheat your oven to 350°F (175°C). Lightly grease a 9x5-inch loaf pan or line a baking sheet with foil for easier cleanup.
Step 2: In a large bowl, combine the ground beef, finely chopped onion, large eggs, milk, breadcrumbs, minced garlic, 1/4 cup ketchup, fresh parsley, Worcestershire sauce, salt, black pepper, and Italian seasoning.
Step 3: Mix all ingredients until just combined. Be careful not to overmix, as this can lead to a tough meatloaf.
Step 4: Shape the mixture into a compact loaf and place it in the prepared loaf pan or directly onto the lined baking sheet.
Step 5: In a small separate bowl, whisk together all the glaze ingredients: 1/2 cup ketchup, brown sugar, white vinegar, garlic powder, and onion powder until smooth.
Step 6: Brush half of the prepared glaze evenly over the top of the meatloaf.
Step 7: Bake for 45 minutes. After 45 minutes, remove the meatloaf from the oven and brush with the remaining glaze.
Step 8: Continue baking for another 15-30 minutes, or until the internal temperature of the meatloaf reaches 160°F (71°C) when measured with a meat thermometer in the thickest part.
Step 9: Once baked, remove the meatloaf from the oven and let it rest for 10-15 minutes before slicing and serving. This allows the juices to redistribute, ensuring a moist and flavorful result. Enjoy!