Step 1: Preheat your oven to 375°F (190°C) and grease a 9x13 inch baking dish with non-stick spray or olive oil.
Step 2: Bring a large pot of salted water to a boil and cook the pasta for 2 minutes less than the package instructions for al dente; drain and set aside.
Step 3: In a large skillet over medium-high heat, cook the ground beef and Italian sausage until fully browned, breaking them into small pieces with a spoon.
Step 4: Drain the excess grease from the skillet, then stir in the pizza sauce, crumbled bacon, garlic powder, and Italian seasoning.
Step 5: Combine the cooked pasta with the meat sauce mixture in the skillet (or a large bowl) and toss until the pasta is evenly coated.
Step 6: Spread half of the pasta mixture into the prepared baking dish. Sprinkle with 1 cup of mozzarella, 1/2 cup of cheddar, and half of the pepperoni slices.
Step 7: Top with the remaining pasta mixture, followed by the remaining mozzarella, cheddar, and the rest of the pepperoni slices.
Step 8: Bake in the preheated oven for 20-25 minutes, or until the cheese is melted, bubbly, and slightly golden on top. Let rest for 5 minutes before serving.