Step 1: Pat the chicken tenderloins dry with paper towels.
Step 2: In a large bowl or a resealable bag, combine the chicken tenderloins with the buttermilk, 1 teaspoon salt, and 1/2 teaspoon black pepper. Make sure all pieces are coated. Cover and refrigerate for at least 30 minutes, or up to 4 hours.
Step 3: Set up your breading station. In a shallow dish, combine the all-purpose flour, paprika, garlic powder, onion powder, remaining 1 teaspoon salt, and remaining 1/2 teaspoon black pepper. Whisk well to combine.
Step 4: In a second shallow dish, place the Panko breadcrumbs.
Step 5: Remove a chicken tender from the buttermilk, allowing any excess to drip off. First, dredge it thoroughly in the seasoned flour mixture, ensuring it's completely coated. Shake off any excess flour.
Step 6: Immediately transfer the floured tender to the Panko breadcrumbs. Press the Panko firmly onto all sides of the chicken, ensuring a thick, even coating. Repeat with all chicken pieces. Lay the breaded chicken tenders on a clean plate or baking sheet.
Step 7: To pan-fry: Heat about 1 inch of vegetable oil in a large, heavy-bottomed skillet or cast-iron pan over medium-high heat until it reaches 350-375°F (175-190°C).
Step 8: Carefully place the breaded chicken tenders into the hot oil, ensuring not to overcrowd the pan. Cook in batches if necessary. Fry for 3-4 minutes per side, or until golden brown and cooked through. The internal temperature should reach 165°F (74°C).
Step 9: To bake: Preheat your oven to 400°F (200°C). Place a wire rack on a baking sheet and lightly spray it with cooking spray. Arrange the breaded chicken tenders in a single layer on the wire rack, ensuring they are not touching. Lightly spray the tops of the tenders with cooking spray.
Step 10: Bake for 18-25 minutes, flipping halfway through, or until golden brown and the internal temperature reaches 165°F (74°C).
Step 11: Remove the cooked chicken tenders from the oil or oven and place them on a plate lined with paper towels to drain any excess oil. Serve immediately with your favorite dipping sauces!